Compare 77 commercial peptide synthesizer and cleavage instruments across 16 manufacturers, including automated peptide synthesizer, SPPS synthesizer, and scale-up peptide synthesis equipment options. Public database last updated June 2026.
Important note
This database is for informational comparison only and is compiled from public vendor materials. Specifications can change and may contain errors; verify details directly with the manufacturer before purchasing, operating, or relying on any system. Inclusion does not imply endorsement, certification, or affiliation. To report an error, request a correction, or suggest an instrument or manufacturer that should be added or removed, please use the Contact Us page. Some large-scale systems publish reactor volume rather than peptide mmol scale, so they remain visible only when the scale range is unbounded.
Peptide Synthesizer Model Index
This crawlable index lists peptide synthesizers, automated peptide synthesizer platforms, SPPS synthesizer systems, solid phase peptide synthesis synthesizer options, and peptide synthesis equipment included in the interactive finder.
| Manufacturer | Model | Scale | Synthesis mode | Heating | Chemistry |
|---|---|---|---|---|---|
| CEM | Liberty Blue 2.0 | 0.005-5 mmol; requires two vessel sizes; <4 min/AA at 0.1 mmol | Single (sequential; HT4/HT12 upgrades) | Microwave | Fmoc |
| CEM | Liberty PRIME 2.0 | 0.005-5 mmol; requires two vessel sizes; <4 min/AA at 0.1 mmol, 2.5 min in comparison table | Single (sequential; HT4/HT12/HT24 upgrades) | Microwave | Fmoc |
| CEM | MultiPep 1 | Scale range 0.001-0.3 mmol; plates up to 96 peptides at 1-10 µmol; columns up to 48 at 1-10 µmol or 8 at 10-300 µmol; SPOT up to 1200 peptides; CelluSpots up to 768 | Parallel + SPOT array | Room temp (optional heating module for plates/columns) | Fmoc; PNA support |
| Biotage | Initiator+ Alstra | 5 µmol-2 mmol; reaction volumes 0.6-20 mL across 5/10/30 mL disposable vials | Single; full automated cycles or manual control of key steps | Microwave | Fmoc & Boc; peptoids, PNA, peptidomimetics; cyclic and branched peptides via Branches software |
| Biotage | Initiator+ Peptide Workstation | 50-500 µmol overall; 2-5 mL vial for 75-150 µmol and 10-20 mL vial for 250-500 µmol | Manual / semi-manual microwave SPPS and cleavage | Microwave (via Initiator+ microwave synthesizer) | Fmoc & Boc; solution and solid-phase synthesis; post-synthetic modifications; PNA, peptoids and organic synthesis |
| Biotage | Syro I | 1-600 µmol per vial; reactor vessels 0.4-20 mL; standing blocks for 2/5/10 mL vials | Parallel | Room temp; optional heating block | Fmoc & Boc |
| Biotage | Syro II | 1-600 µmol per vial; reactor vessels 0.4-20 mL; two standing blocks for 2/5/10 mL vials | Parallel (HTP, dual-arm) | Room temp; optional heating block | Fmoc & Boc |
| Gyros Protein Technologies | PurePep Chorus | 0.005-1.0 mmol per reaction vessel; 2/4/6 RV configurations give 2/4/6 mmol total capacity | Parallel (2/4/6 configurable RVs) | Independent induction heating with optional oscillating shaker mixing | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| Gyros Protein Technologies | Symphony X | 0.005-24 mmol; 24 RVs, 12 with pre-activation option; up to ~2 g resin per RV | Asynchronous-independent (24 ch) | Optional infrared (IR) heating | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| Gyros Protein Technologies | Symphony / Symphony Quartet | 0.005-7.5 mmol; 2.5 mmol for Symphony Quartet | Parallel (12 RV; 4 for Quartet) | Room temp | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| Gyros Protein Technologies | Prelude X | 0.005-1.0 mmol per reaction vessel; 6 mmol total | Parallel (6 RV; semi-independent options) | Optional six individually controlled induction heating units | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| Gyros Protein Technologies | Tribute UV-IR | 0.005-2.0 mmol; up to 2.1 g resin per reaction vessel | Parallel (2 RV) | Optional infrared (IR) heating | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| Gyros Protein Technologies | PurePep Sonata+ | 1-200 mmol | Single mid-scale synthesis | Room temp; heating not advertised on accessible page | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| Gyros Protein Technologies | PS3 | 0.005-1.5 mmol at 2x excess | Sequential / legacy 3-RV | Room temp | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| AAPPTec | Focus XC | 0.01 – 5 mmol per reactor (vendor solution page; older brochures cite 0.05–30 mmol) | Parallel (1/2/4/6) | Optional heating/cooling/microwave (per config) | Fmoc & Boc |
| AAPPTec | Focus XCi | 5.0-50.0 mmol resin; production-scale, up to 100 g/hundreds of grams claimed by AAPPTec sources | Single (production scale) | Optional heating/cooling | Fmoc & Boc |
| AAPPTec | Endeavor 90 III | Up to 200 mmol peptide in a single synthesis; 1 L and optional 2 L reactors process up to 100 g resin; minimum scale not published | Single (scale-up) | Not published in accessible AAPPTec Endeavor 90 III page | Fmoc & Boc |
| AAPPTec | Apex 396 / 396HT | 1 mg – 1 g per peptide (mmol values are derived estimates) | Parallel (up to 96/192/384) | Room temp | Fmoc & Boc |
| AAPPTec | Matrix 384 | small µmol | Parallel (up to 384) | Room temp | Fmoc & Boc |
| AAPPTec | Titan 357 | 36 parallel reaction vessels; 550 mL scale-up/main reaction vessel; split-combine libraries up to millions of compounds; multi-gram single peptides | 3-in-1: parallel, scale-up, split-and-combine combinatorial | Room temp; optional temperature-controlled amino acid vessels | Fmoc & Boc |
| AAPPTec | Triton | 5-250 mg resin on product page; brochure states up to 500 mg resin; 32 x 5 mL or 18 x 10 mL disposable syringe-barrel reactors | Parallel centrifugal synthesis | Room temp | Fmoc & Boc |
| AAPPTec | Model 400 | Pilot-production scale; exact reactor volume and peptide mmol scale not published on accessible model page | Single (pilot-production) | Custom configuration; exact heating mode not published | Fmoc & Boc |
| CS Bio | CSBio II | 0.1 mmol example (~175 mg crude 20-mer); vendor does not publish full mmol range | Single | Conductive-heated RV + pre-heated solvent delivery | Fmoc & Boc; supports branched, cyclized, glycopeptides, N-methyl peptides, PNA, peptoids, long peptides >100 AA, thioesters and phosphopeptides |
| CS Bio | CS136X | 20-200 mL reaction vessels; R&D, process development, and small-scale manufacturing; estimated ~0.1-10 mmol | Single; optional multi-vessel parallel | Conductive-jacketed / heat-exchanger temperature control | Fmoc & Boc |
| CS Bio | CS136M | 6 x 20-100 mL reaction vessels; high-throughput small-scale manufacturing; estimated ~0.1-5 mmol per RV | Parallel (6 vessels) | Room temp; heated/chilled jacketed reaction vessels optional | Fmoc & Boc |
| CS Bio | CS336X | Discontinued CS336X; CS Bio China news page states the new CSBio II replaces CS336X | Discontinued / replaced | Not published in accessible CS Bio China replacement notice | Fmoc & Boc |
| CS Bio | CS536X | 200 mL-1 L or 500 mL-2 L reaction vessel; gram quantities of purified peptide; pilot/process development | Single-batch pilot scale | Conductive temperature control / solvent preconditioning optional | Fmoc & Boc |
| CS Bio | CS936S | 2-10 L reaction vessel; pilot scale through GMP-ready clinical-stage production | Single-batch pilot / clinical-stage production | Conductive temperature control optional | Fmoc & Boc |
| Activotec | Activo-P11 | 0.005-5.0 mmol | Single | Automated reactor heating | Fmoc or t-Boc; PNA support |
| Activotec | Activo-P14 | 0.05-5.0 mmol | Semi (single) | Reactor heating | Fmoc or t-Boc; PNA support |
| Activotec | Activo-PLS | 0.05-3.0 mmol peptide scale (PDF); product page also lists 0.5-50 mL reaction-volume configurations | Parallel | Heating/cooling PLS blocks | Fmoc and Boc peptide synthesis; parallel reaction chemistry |
| Biotage | SyroWave | Conventional parallel synthesis in 2/5/10 mL vials; tip synthesis module for 96 peptides at 1-5 µmol; older sources cite up to 300 µmol vial classes | Parallel + microwave-assisted step transfer | Microwave + optional Syro heating blocks | Fmoc & Boc; difficult sequences; conventional SPPS plus microwave-assisted couplings |
| MultiSynTech | SAM | 5-200 µmol per reactor stated in text; specification table cites 0.05-0.3 mmol | Semi-automated parallel | Room temp | Fmoc & Boc compatible; parallel solid-phase peptide synthesis |
| Vapourtec | Peptide-Builder | 0.05-1.00 mmol; up to 16 peptides queued sequentially | Fast-flow sequential; unattended queue up to 16 peptides | Flow-heated VBFR | Fmoc/tBu SPPS; DIC/Oxyma activation |
| Vapourtec | Peptide-Explorer | 0.05-1.00 mmol | Fast-flow single synthesis / method development | Flow-heated VBFR | Fmoc/tBu SPPS; DIC/Oxyma activation |
| Vapourtec | PS-30 (Peptide-Pilot) | 2-30 mmol; ~9-140 g resin loading | Fast-flow single synthesis / pilot scale | Flow-heated VBFR | Fmoc/tBu SPPS; DIC/Oxyma activation |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Atlas 2 | 0.1-3 mmol; 25/50 mL and 100/200/500 mL reactor classes | Asynchronous / independent multichannel | Water bath / electromagnetic induction | Fmoc & Boc |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Atlas 6 | 2-60 mmol; Type I 0.5-2 L and Type II 1/2/5 L reactor classes | Single (pilot) | Water bath | Fmoc & Boc |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Atlas 8 | 25-250 mmol; 5-20 L reactor volume | Single (production) | Water bath | Fmoc & Boc |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Sirius | ≥0.3 mol; 30-2000 L reactor volume | Single (industrial production) | Water / ethylene glycol temperature medium | Fmoc & Boc |
| Buchiglas (Büchi AG) | Peptide synthesizer reactor solutions (5-500 L) | Peptide synthesizer reactor solutions; 5-500 L filtration vessels; standardized FR 10/30/50 portfolio plus customized manual or fully automated systems | Single production reactor; manual or fully automated batchwise SPPS | Heating/cooling jacket; optional heatable bottom plate | SPPS reactor platform; Fmoc/Boc chemistry not specifically constrained by vendor page |
| TETRAS / Occam Design | TETRAS | 30-1000 µmol or 0.01-3 g resin; 7/40/60 mL reactor classes | Asynchronous parallel | Room temp; heating capabilities / TETRAS heating option depending configuration | Fmoc & Boc |
| PeptiSystems | PeptiPro | 10 mmol-5 mol in detailed product text; overview also states up to 10 mol per batch | Flow-through single synthesis; sequential non-stop operation with two column positions | Flow-heated liquid stream | SPPS peptide chemistry; uses standard SPPS reagents, resins, and solvents |
| AAPPTec | P4-400 | Large production scale; P4-400 brochure states 20-100 g resin, 100 g-3 kg resin, >3 kg resin, standard RV 2-50 L, and vessels/containers interchangeable up to 200 L+; peptide mmol scale not published | Single (large production) | Custom configuration; exact heating mode not published | Fmoc & Boc; custom protocols |
| Vapourtec | Peptide-Scaleup | 0.5-5.0 mmol; typical 30-mer at 4 mmol in 16 h | Fast-flow single synthesis / scale-up | Flow-heated VBFR | Fmoc/tBu SPPS; DIC/Oxyma activation |
| CEM | Liberty Lite 2.0 | 0.005-5 mmol; requires three vessel sizes; 12 min cycle at 0.1 mmol | Single (sequential; HT4 upgrade) | Microwave | Fmoc; CarboMAX carbodiimide coupling; post-synthesis modifications supported |
| CEM | Liberty PRO | 3, 8, or 15 L reaction vessels; up to 1 kg crude peptide per batch; examples include 800 mmol 10-mer and 250 mmol 35-mer on 15 L reactor | Single (production) | Microwave | Fmoc / CarboMAX (vendor page); microwave coupling/deprotection |
| CEM | MultiPep 2 | Scale range 0.001-0.5 mmol; plates up to 384 peptides at 1-10 µmol; mini-columns 1-15 µmol; 48 columns 1-500 µmol; 72 columns 1-300 µmol; SPOT up to 2400; CelluSpots up to 768 | Parallel + SPOT array | Room temp (optional heating module for plates/columns) | Fmoc; PNA support |
| CEM | Discover SPPS | 25 mL vessel optimized for 0.1 mmol; flexible manual SPPS method development | Manual / stepwise | Microwave | Fmoc & t-Boc; microwave deprotection/coupling/cleavage |
| AAPPTec | Vantage | 1 mg to grams; 1-96, 1-192, or 1-384 peptides simultaneously; 48 or 96 reactors | Parallel / high-throughput | Heating/cooling reactor assembly | Peptide, PNA, DNA, sugar chemistry, organic chemistry; modified peptides/stapled peptides |
| AAPPTec | Eclipse | 10-500 mg resin | Single / personal research-scale | Heating capability | Fmoc & Boc; custom coupling chemistry supported |
| AAPPTec | Focus Xi | 25 mg to 10 g resin; up to 300 peptides/year | Single / personal research-scale | Optional heating, heating/cooling, or sonication module | Fmoc & Boc |
| MultiSynTech | SAP | 0.5-20 mmol; page body also states 0.5-15 mmol | Single / semi-automated | Room temp | Fmoc & Boc compatible; solid-phase peptide synthesis |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Nova 1 | 25/50 mL and 50/100/250 mL reactor classes; mmol scale not stated on accessible page | Sequential single-channel | Electromagnetic induction / water bath | Fmoc & Boc |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Nova 3 | 0.1-0.6 mmol Basic or 0.1-0.5 mmol Upgraded | Asynchronous / independent parallel | Electromagnetic induction (Basic) or hot air (Upgraded) | Fmoc & Boc |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Nova 5 | 0.1-1.5 mmol; 30/120 mL reactor volume | Sequential microwave synthesis | Microwave | Fmoc & Boc |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Nova 7 | 0.1-0.6 mmol; 10/30 mL reactors; upgradeable | Asynchronous high-throughput parallel | Hot air (whole unit) | Fmoc & Boc |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Atlas 4 | 2-25 mmol; 0.5-2 L reactor volume | Dual-channel pilot synthesis | Water bath / electromagnetic induction | Fmoc & Boc |
| Vapourtec | Peptide-ExplorerLT | 0.05-1.00 mmol; linear peptides; no automated side-chain addition | Fast-flow single synthesis for linear peptides | Flow-heated VBFR | Fmoc/tBu SPPS; DIC/Oxyma activation |
| Activotec | Activo-Darwin | 0.05-5.0 mmol specification; page headline mentions 0.05-20.0 mmol but directs >5.0 mmol to Darwin LS | Semi (single) | Reactor heating | Fmoc or t-Boc; PNA support |
| Activotec | Activo-Darwin LS | 1.0-20.0 mmol | Semi (single large-scale) | Room temp; heating not advertised on accessible page | Fmoc or t-Boc; PNA support |
| Activotec | Activo-P12 Cleavage Device | Direct cleavage from Activotec disposable reactors; mmol scale not published | Cleavage | Room temp; heating not advertised | Peptide cleavage / deprotection workflow |
| CEM | Razor | Up to 12 peptides in parallel; mmol scale not published | Cleavage | Elevated-temperature cleavage | Peptide cleavage / deprotection workflow |
| CEM | CleavagePro | Up to 48 peptides in parallel; compatible with MultiPep 1/2 column vessels | Cleavage | Room temp; heating not advertised | Peptide cleavage / deprotection workflow |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Aquila | 0.1-10 mmol cleavage scale; 6 channels | Cleavage | Room temp; heating not advertised | Peptide cleavage / deprotection workflow |
| Peptide Scientific (PSI) / Beijing Dilun | PepAxis-Aquila S | 0.1-3.6 mol cleavage scale; 20-250 L cleavage reactor | Cleavage | Dual-jacket temperature control | Peptide cleavage / deprotection workflow |
| Gyros Protein Technologies | Sonata / Sonata XT | 0.05-100 mmol; 200 mmol on Sonata XT | Single scale-up synthesis | Room temp; heating not advertised on accessible page | Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA |
| PeptiSystems | PeptiPilot | 0.1-12 mmol; method transfer to PeptiPro for production-scale synthesis up to 5 mol | Flow-through single synthesis for process development and small-scale production | Flow-heated liquid stream | SPPS peptide chemistry; uses standard SPPS reagents, resins, and solvents |
| Goel Scientific Glass Works / Goel Impex | Peptide Synthesizer | Peptide synthesizer page states small-to-medium reactor volumes, e.g. 1-50 L; related Goel equipment page also lists Glass ANF/kilo-lab options from 10-300 L working volume | Single custom automated glass-reactor SPPS | Conductive temperature-controlled glass reactor; ambient to ~80 °C typical SPPS conditions | Solid-phase peptide synthesis (SPPS) |
| Arrayit | Peptide Synthesizer Model PSP510 | 10 peptides per run; peptide mmol scale not published | Parallel manual / semi-automated peptide synthesis | Ambient shaker; PSP510 page does not publish heating | Peptide synthesis for microarray manufacturing and life-science research; exact chemistry not specified |
| Peptide Machines | Discovery-4 | 0.05-3.0 mmol per reactor; 4 independent reactors | Parallel; independent reactors and protocols | Ambient | Fmoc; common coupling reagents including HBTU, HATU, PyBOP, DIC/HOBt; bulk AA solutions up to 0.5 mmol concentration |
| Peptide Machines | Discovery-12 | 0.05-1.0 mmol per reactor; 12 independent reactors | Parallel HTP; independent reactors and protocols | Ambient | Fmoc with or without pre-activation; common coupling reagents including HBTU, HATU, PyBOP, DIC/HOBt; bulk AA solutions up to 0.5 mmol concentration |
| Peptide Machines | Presto-100 | 1-20 L reactor volume; peptide mmol scale not published | Single scale-up / process-development SPPS; automatic cleavage on instrument | Jacketed reactor heating | Fmoc, t-Boc, and custom protocols |
| Peptide Machines | Presto-150 | 5-50 L reactor volume; peptide mmol scale not published | Single pilot / production SPPS; automatic cleavage on instrument | Jacketed reactor or circulation heating | Fmoc, t-Boc, and custom protocols |
| Activotec | Activo-S44 | 0.05-2.0 mmol | Single automated organic synthesis | Reactor cooling/heating | Wide range of solid-phase organic chemistries |
| Torviq | Domino Block Synthesizer | Parallel solid-phase synthesis using 2.5, 5, 20, or 50 mL syringe reaction vessels; peptide mmol scale not published | Manual / semi-automatic parallel solid-phase synthesis | Ambient; external shaker/tumbler/oven optional | Solid-phase organic synthesis; compatible with peptide/SPPS-style resin workflows where user chemistry permits |
| Torviq | La Marast Synthesizer | 3-30 g resin; 100, 200, and 450 mL conical-tube reaction vessels | Manual parallel solid-phase synthesis | Ambient; external shaker/tumbler/oven optional | Solid-phase organic synthesis; compatible with peptide/SPPS-style resin workflows where user chemistry permits |